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KMID : 0386520120200020017
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Research Institute of Korean Medicone
2012 Volume.20 No. 2 p.17 ~ p.27
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Study of KMSMT on anti-inflammaory effect
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Bak Ji-Won
Gim Seon-Bin
Kim Eun-A
Jun Ji-Ae
Lee Ki-Moo
Kim Dong-Hee
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Abstract
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In order to investigate the possibility of Kamisamultang(KMSMT) as therapeutic for the treatment of atopic dermatitis(AD), cytotoxicity, anti-oxidant activity, modulatory and suppression activities of KMSMT were tested. 90% or higher cell viability was observed in all tested groups from 25 to 200 using Raw 264.7 cells. KMSMT showed dose-dependent DPPH scavenging activity, with more than 80% scavenging activities at 400 and 800 concentrations. KMSMT showed dose-dependent suppression activity of reactive oxygen species(ROS) production, especially at 200 of 42.6%. KMSMT decreased nitric oxide(NO) production activity dose dependently, expecially at 200 of 30.9%. IL-, IL-6, MCP-1, TNF- production rate were decreased by 45.7%, 15.5%, 8.9%, 16.5% respectively when Raw 264.7 cells were treated with LPS and with KMSMT of 200 . However, only IL- and MCP-1 showed significant changes. The results above strongly suggest the modulatory and suppressive effect of KMSMT. The results above indicate that KMSMT significantly reduces the effect of oxidative and inflammatory cytokines. The use of KMSMT in atopic dermatitis can be widely suggested.
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KEYWORD
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KMSMT(Kamisamultang), atopic dermatitis, oxidative damages, inflammation
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